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The Journal

In-depth writing from our medical reviewer.

Long-form pharmacology, clinical safety, and historical case studies. Every post authored or medically reviewed by Mad Honey Finder Editorial

Topics: pharmacology clinical safety protocol history
The Pharmacokinetics of Grayanotoxin: What Happens in Your Body After a Spoonful of Mad Honey
pharmacology

The Pharmacokinetics of Grayanotoxin: What Happens in Your Body After a Spoonful of Mad Honey

After ingestion, grayanotoxin I — the dominant active in mad honey — is absorbed from the GI tract within 30–90 minutes, binds to voltage-gated sodium channels

Mad Honey Finder Editorial 9 min read
Drug Interactions with Mad Honey: The Medications You Must Never Combine
clinical

Drug Interactions with Mad Honey: The Medications You Must Never Combine

Mad honey should not be combined with beta-blockers, calcium-channel blockers, digoxin, or non-dihydropyridine antihypertensives — the combined cardiac depressi

Mad Honey Finder Editorial 8 min read
Cardiac Effects of Mad Honey: Bradycardia, AV Block, and Recovery
clinical

Cardiac Effects of Mad Honey: Bradycardia, AV Block, and Recovery

The most common cardiac effects of mad honey are sinus bradycardia (heart rate below 60) and transient first-degree AV block. Hypotension is nearly universal at

Mad Honey Finder Editorial 7 min read
Mad Honey and Pregnancy: An Evidence-Based Safety Review
safety

Mad Honey and Pregnancy: An Evidence-Based Safety Review

Mad honey should be avoided during pregnancy and breastfeeding. Grayanotoxin is lipophilic, crosses the placenta, and produces the same cardiovascular effects i

Mad Honey Finder Editorial 7 min read
First-Time User Clinical Checklist: What to Do Before Your First Spoonful
protocol

First-Time User Clinical Checklist: What to Do Before Your First Spoonful

Before a first mad-honey dose: review medications for cardiac/CNS/PDE5 interactions, confirm you are not pregnant or breastfeeding, measure baseline blood press

Mad Honey Finder Editorial 6 min read
Dose-Response Curves for Grayanotoxin: What the Research Actually Shows
pharmacology

Dose-Response Curves for Grayanotoxin: What the Research Actually Shows

Grayanotoxin dose-response is non-linear because the target (voltage-gated sodium channels) saturates. The curve is shallow in the low-dose range (mild symptoms

Mad Honey Finder Editorial 6 min read
Emergency Protocol: What To Do If Someone Has Taken Too Much Mad Honey
protocol

Emergency Protocol: What To Do If Someone Has Taken Too Much Mad Honey

If someone has taken too much mad honey: lay them flat with legs elevated, check pulse and breathing, call emergency services if pulse is below 45, they have ch

Mad Honey Finder Editorial 6 min read
The Xenophon Incident: Mad Honey's First Documented Mass Exposure
history

The Xenophon Incident: Mad Honey's First Documented Mass Exposure

In 401 BCE, Greek soldiers under Xenophon marching through the Pontic region (modern Turkey's Black Sea coast) ate local honey and suffered mass intoxication. X

Mad Honey Finder Editorial 6 min read